There really needs to be an Uncharted 5. The way Uncharted 4: A Thief's End concluded, there's plenty of room for many more stories if Naughty Dog thinks about it the right way.

Sam Drake and Viktor O'Sullivan obviously teamed up and done a few jobs together before retiring when Cassie Drake was still a child.

Then there's Cassie Drake..... She's got plenty of adventures in front of her! Some with her father (possibly even her mother), and no doubt some solo adventures with other introduced characters and/or familiar faces.