Even though Fisk doesn't have any superpowers, Kingpin is described as having peak human, “near superhuman” strength and is composed almost entirely of muscle. He's a skilled fighter, and he possesses unusual speed and grace for his size. His bulk serves a crucial purpose too, providing Fisk with padding from most forms of injury. Kingpin's criminal genius is also a major factor in what makes him hard to beat, with armies of henchmen, scientists and several superhumans all loyal to him and at his disposal. Add in Fisk's influence of the law system and it makes him a difficult man to put behind bars.

10. The Lizard

Borne of Stan Lee's love for both gothic literary classics such as Dr. Jekyll and Mr. Hyde, The Lizard is one of many cases in Peter's life where a friend or mentor goes rogue and has to be taken down by Spider-Man. Dr. Curtis Connors works on a formula involving lizard DNA to crack the reptilian secret of limb regrowth. His experiment works and the good doctor regrows his missing arm, but is turned into a large humanoid lizard in the process. In his original state, Connors lost his higher brain function when transformed, becoming a snarling, savage beast, but later comics have played around with Connors' level of mental control.

As the Lizard, Connors is granted superhuman strength, speed, durability and agility as well as razor-sharp fangs and claws. He can also take an immense amount of punishment, with his regenerative healing factor working overtime to repair any injury and regrow any damaged limb.

9. Kraven the Hunter

Sergei Kravinoff is a former Russian aristocrat, who abandoned his dying dynasty in favor of becoming a great hunter. After he has successfully hunted Earth's toothiest and most dangerous creatures, his focus shifts to Spider-Man, who he believes will be the jewel of his collection. In preparation for the hunt, he drinks an elixir given to him by Calypso, a voodoo priestess, and gains a host of superhuman abilities, including enhanced strength and a drastically slowed aging process.

Kravinoff was already scarily skilled as a hunter, fighter and marksman, but the elixir heightened these, enabling him to track and trap Spidey as well as be able to go toe-to-toe with him. Despite his skill and fantastic facial hair, Kraven is never able to beat Spider-Man and becomes frustrated, leading to the memorable Kraven's Last Hunt storyline, where Kraven appears to shoot Spider-Man and bury him. He adopts the Spidey costume and goes on a “heroic” spree, hospitalising criminals and even killing one. He also apprehends minor supervillain Vermin single-handedly. When Spider-Man wakes up after what transpires to be a tranquilizer, Kraven explains that he's made his point and regained his honor before he commits suicide.

Of all of Spidey's principal adversaries, we think Kraven the Hunter would make for sorry Vulture).

8. Sandman

William Baker aka street crook Flint Marko won the super powers lottery whilst fleeing the authorities. In his first appearance in Amazing Spider-Man # 4 (1963), Marko hides from the law in a testing site. A nuclear bomb explodes nearby and the radioactive energy of it causes him to merge with the sand beneath his feet. As a result of this, Marko becomes a shape-shifter, now imbued with the ability to manipulate his size and form at will.

Despite being embarrassingly defeated by Spidey using a vacuum cleaner in his first appearance, Flint Marko grew to pose a significant threat to Spider-Man. Marko's command of sand makes him an incredibly tough opponent. His control of his density means that he can be the consistency of a sandcastle one minute and be as tough as sandstone the next, making him resistant to physical attacks in both forms as well as superhumanly strong. He can use nearby sand to repair any damage taken in battle and, given enough, can increase his size and volume exponentially. Whilst he's weak to common things like water, Sandman has proved incredibly difficult to ultimately defeat, as he's also able to reassemble himself from a few grains of sand.

7. Rhino

Aleksei Sytsevich firmly belongs in the “big but dumb” camp of villains. Sytsevich was introduced in Amazing Spider-Man #41 (1966) as a Russian mobster who is selected due to his size and low intelligence to undergo severe chemical and radiation treatments to transform him into a superhuman. His armor is modelled after a rhinoceros' hide and it becomes permanently bonded to his skin.

Rhino is incredibly strong, capable of lifting 75-100 tons, completely eclipsing Spider-Man's strength. Sytsevich is able to charge at great speeds, making him a dangerous opponent. He's also as durable as a tank, able to withstand high caliber gunfire as well as extreme temperatures. To cap it off, he has a nifty horn on his head for goring. More modern interpretations have updated the suit to be more of a robot exoskeleton, but his raw strength remains consistent.

6. Electro

Maxwell Dillon has always been about the Almighty dollar. After agreeing to help a fellow electrical lineman in trouble for a fee, Max ends up being hit by a bolt of lightning at the top of a pylon and becomes a living capacitor for electricity, able to shoot high voltage electric blasts as well as having the ability to turn into pure energy and escape via wires and sockets. Dillon naturally uses these gifts to super-ignore people in need of help, and takes to robbing banks for the benefit of his wallet.

When fully charged, Electro is superhumanly strong and fast. At one point in the comics, he undertakes an experimental procedure that enhances his powers significantly. Dillon gained the ability to absorb and produce limitless energy. As another change, he is also able to use electromagnetic fields to move and throw objects, making him even tougher to take down.