Grey's Anatomy season 21 will feature several popular returning characters, like Meredith Grey and Miranda Bailey, who have appeared since the medical drama's very first season in 2005. However, the new installment will also feature characters that have not been seen in a long time.

Grey's Anatomy season 21 is set to feature reappearances by both Kali Rocha and Jesse Williams, who were once series regulars but have since left the show. The season will also address the Grey's Anatomy season 20 finale that ended in mass firings and dramatic love triangles. The new and returning characters in season 21 are sure to be a part of Grey's Anatomy's strongest cast yet.

Ellen Pompeo as Dr. Meredith Grey

Date Of Birth: November 10, 1969

• Active Since: 1995

Actor: Ellen Pompeo was born in Massachusetts, and had her first screen appearance on Law & Order. She guest-starred on several shows, including Friends and Strong Medicine, until she broke big in Moonlight Mile in 2002. Her appearance in Moonlight Mile led to her being cast as Meredith Grey in Grey's Anatomy.

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Character: Pompeo has played the lead in Grey's Anatomy since the show's premiere in 2005. Her notable character relationships include her friendship with Dr. Christina Yang and her relationship with Dr. Derek Shepherd. Meredith is a highly intelligent and complex character who sees the world in nuances.

Chandra Wilson as Dr. Miranda Bailey

Date Of Birth: August 27, 1969

• Active Since: 1989

Actor: Chandra Wilson was born in Texas and started her career on stage in off-broad performances. Her first television appearances include minor roles on The Cosby Show and Law & Order. She also appeared in the movie Philadelphia, but despite her significant praise, her breakout role was as Dr. Miranda Bailey in Grey's Anatomy in 2005.

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Character: Bailey is a selfless and loyal character on Grey's Anatomy and often puts others' needs before her own. She is a major part of the hospital, and it is nearly impossible to imagine how Grey Sloan Memorial would run without her. Wilson's Bailey has also appeared in several Grey's Anatomy spinoffs.

James Pickens Jr. as Dr. Richard Webber

Date Of Birth: October 26, 1954

• Active Since: 1981

Actor: James Pickens Jr. was born in Ohio, and he had his first breakout role in the soap opera Another World. Pickens also guest-starred on several shows, including The X-Files and JAG. Pickens has a wide portfolio of acting credits, but he is best known for his role as Dr. Webber.

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Character: Richard is the attending general surgeon at Grey Sloan Memorial Hospital. He routinely acts as a mentor to several characters. His most notable relationship in season 21 is his relationship with Catherine Fox, as he is her husband and the Chief Medical Officer of the Catherine Fox Foundation.

Kevin McKidd as Dr. Owen Hunt

Date Of Birth: August 9, 1973

• Active Since: 1991

Actor: Kevin McKidd was born in Moray, Scotland, and he had his first major acting role in Trainspotting. McKidd has portrayed both serious and lighthearted characters. His notable roles include his voice acting in Brave and his portrayal of Andrew Bloom in It Ends With Us. The actor ed the ensemble cast in Grey's Anatomy in season 5.

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Character: Owen is an excellent doctor who struggles with personal relationships. His most notable relationships include his broken marriage with Christina Yang and his divorce from Teddy Altman. He is assertive and stubborn, which helps his patients but wreaks havoc on his love life.

Caterina Scorsone as Dr. Amelia Shepherd

Date Of Birth: October 16, 1981

• Active Since: 1989

Actor: Caterina Scorsone was born in Toronto, Canada, and had her first television debut in the children's program, Mr. Dressup. Her breakout role was in 1-800-Missing, where she played the lead. Scorsone has also appeared in several movies, including Crash and The November Man.

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Character: Amelia was first introduced to Grey's Anatomy through its spinoff, Private Practice. Amelia is the late Dr. Derek Shepherd's sister. As a result, she is closely connected to Meredith Grey and their surrounding mutual friends.

Camila Luddington as Dr. Jo Wilson

Date Of Birth: December 15, 1983

• Active Since: 2007

Actor: Camilla Luddington was born in Berkshire, England, and had her first major role as Kate in William & Kate: The Movie. Luddington broke big when she was cast as the voice of Lara Croft in the Tomb Raider video game. She ed the Grey's Anatomy cast in season 9.

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Character: Jo is a bubbly and friendly doctor who gets along well with the other Grey's Anatomy season 20 finale.

Jason George as Dr. Ben Warren

Date Of Birth: February 9, 1972

• Active Since: 1997

Actor: Jason George was born in Virginia, and he broke big in Sunset Beach as Michael Bourne. George has appeared in a variety of shows and movies and his most notable appearances include his roles in Mistresses and Station 19.

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Character: Ben has played both a doctor and a firefighter in Grey's Anatomy. He is best known for being Miranda Bailey's loving husband. Ben was first introduced to Grey's Anatomy as a ing character in season 6 and later became a series regular.

Kim Raver as Dr. Teddy Altman

Date Of Birth: March 15, 1969

• Active Since: 1975

Actor: Kim Raver was born in New York City, and had her first major role as a child on Sesame Street. She later appeared in several Broadway performances, and she had her first major movie role in City Hall. Raver is best known for her role as Audrey Raines in 24.

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Character: Teddy is a complicated character on Grey's Anatomy. She is a highly skilled doctor, but she also struggles in her personal relationships, similar to her ex-husband Owen Hunt. Teddy ed the cast in season 6.

Jake Borelli as Dr. Levi Schmitt

Date Of Birth: May 13, 1991

• Active Since: 2007

Actor: Jake Borelli was born in Ohio, and he had his first breakout role in The Thundermans. Borelli has appeared in several movies, including #Realityhigh and The Thing About Harry. He is best known for his role as Dr. Levi Schmitt in Grey's Anatomy.

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Character: Levi is a surgical resident at Grey Sloan who started his career as an intern back in season 17. He is kind and gentle but is often clumsy, which shows up in his work and personal life. His most notable relationship is his romantic relationship with Nico Kim.

Chris Carmack as Dr. Atticus "Link" Lincoln

Date Of Birth: December 22, 1980

• Active Since: 2000

Actor: Chris Carmack was born in Maryland and broke big in the teen drama The O.C. Carmack has appeared in several teen dramas and one of his most notable appearances was in The Butterfly Effect franchise. He ed the Grey's Anatomy cast as Link in season 15.

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Character: Link is a sweet doctor who always wants the best for his patients. He has a complicated relationship with Amelia Shepherd and is currently in a relationship with Jo Wilson. He is also very ive and an attentive father.