Warning: SPOILERS Below For Avengers: Infinity War!
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The ending of Avengers 4!
The most important silver lining to cling to is that Tony Stark, who Thanos kept alive thanks to that deal. But Doctor Strange is a wizard with many tricks up his sleeve, so trust that he's about to pull the greatest rabbit out of his hat.
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Even if the Avengers who still live can't rely on the late sorcerer's machinations, they do retain a few key resources and advantages they can exploit. One of the biggest boons is that somehow, at least five of the six founding Avengers lived through Ant-Man, the Wasp, and Thor's ally Valkyrie who can bolster their ranks.
The Avengers also have the means to get to Thanos: Thor is the only hero who actually came out stronger from Infinity War, and his new weapon Stormbreaker can open the Bifrost. Even if Thor presently has no clue Tony Stark is on Titan with Nebula, they have access to the Guardians' ship, Soul World of the Soul Stone.
Once back on Earth, Stark will not be playing around; the Bleeding Edge armor he wore against Thanos was loaded with enough weaponry to earn the Mad Titan's respect - and Tony wasn't even ready for Thanos. This time, Iron Man will be armed to the teeth. Stark is sure to open his toy chest and bring everything he's got to bear against the purple demigod. Speaking of incredible technology, Wakanda lost their king T'Challa to Thanos' evil, but that means Okoye and M'Baku are sure to want to exact revenge. They will bring all of their kingdom's arsenal of Vibranium weapons and technology to the greatest war Wakanda has ever fought. If Shuri also survived, she could even assume the mantle of Black Panther.
Lastly, though the Avengers have no knowledge of this, the worst hero).
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So while the current circumstances are undoubtedly bleak, the Avengers do have a ton of firepower to hit back against Thanos: the cliffhanger ending doesn't have to mean the fight is over. Although, with any luck, Thanos will somehow cause his own defeat.