With newcomer Ryan Wilder taking up the mantle of Kate Kane's disappearance, it's safe to say her relationship with Alice will be decidedly different. Alice - also known by her birth name of Beth - is perhaps the most beloved character in the Batwoman series, as her villainous nature is the result of a deeply traumatic childhood, leaving fans rooting for her to get both revenge and an eventual redemption arc.
But the chances of this potential redemption appear to have been cut short by the end of Batwoman season 1, which sees Kate Kane - Alice's sister - go missing and be presumed dead. As Kate was the one person who seemed to have a chance at redeeming her unhinged sibling, her disappearance and possible death will no doubt lead to Alice going even further astray, as season 2 has currently hinted towards.
This is especially true given her relationship with the new Batwoman, Ryan Wilder, appears set to be significantly less positive, given that Alice killed Ryan's step-mother and role model. As would be expected, Wilder seems to genuinely despise Alice, even trying to kill her in the second episode of season 2. To her credit, Alice doesn't appear to take any great offense to this, merely noting the new Batwoman's intention and how this may change the game for the villain. While there's a chance Wilder and Alice could grow out of a more bloodthirsty dynamic - especially as Safiyah Sohail appears to potentially be the "true villain" of the season for either kidnapping or killing Kane - it's unlikely they will ever share the kind of bond Kate and Alice did.
But this isn't necessarily a bad thing. It's already been brought up repeatedly in Batwoman season 2 that Kate's dedication to not killing Alice despite everything she did may have been more due to her familial ties to her sister, and her subsequent guilt that Alice was kidnapped and held prisoner for years by August Cartwright without being saved. This is entirely understandable, but also somewhat less morally righteous than solely not wanting to murder her because doing so wouldn't be right. With this in mind, Ryan can potentially show a stronger moral core than Kate by showing Alice mercy despite her obvious hate for the villain.
This could have a surprising effect on Alice, given season 1 made it expressly clear very few people have ever been genuinely kind to her, or suggested she doesn't deserve the life of continual suffering that she was put through for so many years. It seems unlikely that being spared alone would generate a full redemption arc for Alice, but seeing someone not obliged to try and help her for familial reasons - and who in fact may despise her - still treating her as a human worthy of comion could spark something in the Batwoman underdog that fans have been hoping for since her first appearance.